The invention belongs to the technical field of medical and chemical intermediates and related chemistry and relates to a preparation method of a novel beta-naphthyl-containing diarylketone compound. The preparation method is characterized in that 1-chloromethyl naphthalene and derivatives thereof are taken as raw materials to react with phenylacetonitrile compounds in anhydrous organic solvents under the action of metal catalysts, ligands and alkaline, and an obtained product is converted into the beta-naphthyl-containing diarylketone compound under the action of oxidizing agents. The preparation method of the beta-naphthyl-containing diarylketone compound has the advantages of few reaction steps, low raw material price, mild reaction conditions, convenience in operation, high product yield, high product purity and capability of meeting quality requirements on the medical intermediates completely, thereby providing favorable conditions for industrialized production.