The invention discloses a VME-S bus based working table movement control system, and belongs to the technical field of the movement control system for semiconductors and other precision mechanical equipment. The movement control system comprises a man-machine interaction unit, a VME bus machine case, a CPU main control unit, a movement control unit, an optical fiber interface unit and a synchronous exchange control unit. According to the control system, the dispatching of a RapidIO network, the Ethernet, and a synchronous timing network is completed by a synchronous exchange control card; the signal processing, data processing and other algorithms, as well as data communication are completed by a multi-core DSP movement control card in real time rapidly; and the transceiving, preprocessing and data communication of each path of the optical fiber signals are completed by an optical fiber interface card. According to the VME-S bus based working table movement control system, the multi-DSP processing function is realized by the improved movement control card; in addition, the movement control card is matched with the optical fiber interface card and the synchronous exchange control card to complete flexible application configuration of the system; and meanwhile, the movement control system has relatively high compatibility with other systems and products.