The invention discloses a preparation method of 2, 2'-bipyridine-4, 4'-diacrylic acid. The method includes the steps of: 1) adding 2, 2'-bipyridine-4, 4'-diformic acid methyl ester, acetic ester and a catalyst into an organic solvent and performing mixing, introducing protective gas, and carrying out reaction for 25-48h at a temperature of 120-150DEG C and 2-5 standard atmospheric pressure, with the catalyst being a mixture of a platinum carbon catalyst and a palladium catalyst; 2) at the end of the reaction, carrying out hot filtration and concentration on the reaction liquid to obtain 2, 2'-bipyridine-4, 4'-diacrylic acid. The method provided by the invention has the characteristics of simple operation, mild synthesis condition, high yield, a yield of more than 98%, simple synthesis step, no need of nonaqueous treatment, and low overall technological cost. The catalyst adopts a mixture of a platinum carbon catalyst and a palladium catalyst for catalysis, the dosage is small, the catalyst cost consumption is very low, at the same time the mixed catalyst can be used repeatedly up to more than 100 times, and the reuse rate is high.