The invention provides an inorganic and organic hybrid material as well as a preparation method and an application thereof, belongs to the field of nano materials and solves the problems that existing SiO2 drug-loaded materials require to be impregnated multiple times when used for adsorbing fat-soluble drugs, can only adsorb a small quantity of the drugs each time, and is low in efficiency. The inorganic and organic hybrid material is porous SiO2 grafted 2-(2-methoxyethox) ethyl methacrylate amino acid and has a structural formula shown in the formula I. The invention further provides a preparation method of the inorganic and organic hybrid material and an application of the inorganic and organic hybrid material serving as a SiO2 drug-loaded material. The inorganic and organic hybrid material is the organic porous nano SiO2 drug-loaded material, is generated through grafting with amino acid and is different from traditional inorganic SiO2 drug-loaded materials requiring to be impregnated in drug solutions multiple times for sufficient adsorbing of drugs through small pores in silicon balls. The drug-loaded material enables grafted organic hydrophobic groups to coat drug molecules in a water solution environment more efficiently, and the drug loading capacity is greatly improved.