The invention discloses an image pick-up device with two large-format high-frame digital CCDs (Charge Coupled Device) and belongs to the technical field of photo-electronic imaging. The device comprises an image object lens group, a beam splitter prism, an image calibration mechanism and two large-format digital CCD devices, wherein the beam splitter prism equally divides light beam entering an optical system into two ways of beams to enter the two large-format digital CCD devices respectively; an image registration calibration system guarantees registration of two groups of CCD images; and the two large-format digital CCD devices control the exposure moments of the two large-format digital CCDs through a subsequent image capture timing sequence control system, so that the large-format high-frequency image output is realized. The device has the advantages of simple structure, convenience for debugging, high reliability and the like.