The invention relates to a high-intensity high-rigidity light-weight integral machine body structure, which comprises a sandwich wall plate, a long purlin and a frame, wherein the sandwich wall plate is formed by an outer skin, a core material and an inner skin through co-bonding; through the sandwich wall plate, the wall plate rigidity can be improved, and the structure weight can be reduced; in addition, the sandwich wall plate can be horizontally separated or vertically separated according to practical assembly conditions; after the single curing forming of the long purlin and the frame, the bonding and co-curing is performed with the sandwich wall plate to obtain the high-intensity high-rigidity light-weight integral machine body structure. The invention provides the fire-new type high-intensity high-rigidity light-weight integral machine body structure for aeronautics and astronautics devices. On the precise of meeting the use function of the conventional machine body structure, the requirements of light weight, good rigidity and good strength of the machine body are met; high anti-impact capability is realized; meanwhile, the integral machine body structure uses stitching/RFI process or bonding co-curing process so as to reduce the mechanical connection; therefore the assembly workload is reduced; further, the structure completeness requirements are met.