The invention belongs to the fields of health care products and pharmaceutical preparations, and relates to a stibene glucoside (TSG) chewable tablet, and a preparation method and application thereof. The invention relates to the TSG chewable tablet used for preventing and/ or treating diseases such as disturbance of carbohydrate metabolism. The TSG chewable tablet is prepared from 55 to 60 percent of stibene glucoside, 1 to 2 percent of citric acid, 2 percent of aspartame, 3 percent of acesulfame potassium, 20 percent of erythritol, 10 to 13 percent of beta-cyclodextrine, 1 to 2 percent of magnesium stearate, and the balance 70 percent of ethyl alcohol.