The invention discloses a synthetic method of asymmetric 1,4-diarylbutadiyne compounds. A double elimination method is employed in the method; with [alpha]-methylenesulfone and alkynyl aldehyde as raw materials, a series of asymmetric 1,4-diarylbutadiyne compounds are synthesized. The synthetic method is free of heavy metals and is green and environment-friendly. Compared with cross-coupling raw material synthesis with metal acetylides and halogenated terminal alkyne, the method is simple; and compared with a homocoupling reaction of terminal alkyne, the method can be used for synthesizing asymmetric conjugate diyne.