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发明公开
CN106432014A 的动物生存期和存活率的作用。胺基硫醇类化合物及其制备方法和其在辐射防护中的应用 有权 转让

的动物生存期和存活率的作用。胺基硫醇类化合物及其制备方法和其在辐射防护中的应用
摘要：
本发明公开了胺基硫醇类化合物及其制备方法和其在辐射防护中的应用，所述的化合物具有式I的结构： 其中，A1选自：-C(O)NR8-、-S(O)2-NR8-、-S(O)NR8-、-R7-NR8-，A2选自：羰基、磺酰基、亚硫酰基、取代或未取代的C1-6烷基，R1、R2、R5、R6可相同或不同，选自：氢、取代或未取代的C1-C5烷基或杂烷基，n为0-20000的整数，R3、R4独立地选自：氢、X、取代或未取代的C1-6烷基，X选自：F、Cl、Br、I，R7选自：取代或未取代的C1-C6烷基，R8选自：氢、取代或未取代的C1-C6烷基。所述化合物具有降低电离辐射引起的生物损伤的作用，同时还具有延长被辐射
摘要（英）：

The invention discloses an aminothiol compound, a preparation method of the aminothiol compound and application of the aminothiol compound in radiation protection. The compound has a structure shown in the formula I in the description, wherein A1 is selected from -C(O)NR8-, -S(O)2-NR8-, -S(O)NR8- and -R7-NR8-, A2 is selected from carbonyl, sulfonyl, sulfinyl and substituted or unsubstituted C1-6 alkyl, R1, R2, R5 and R6 can be the same or not and are selected from hydrogen and substituted or unsubstituted C1-C5 alkyl or hetero alkyl, n is an integer from 0 to 20000, R3 and R4 are independently selected from hydrogen, X and substituted or unsubstituted C1-6 alkyl, X is selected from F, Cl, Br and I, R7 is selected from substituted or unsubstituted C1-C6 alkyl, and R8 is selected from hydrogen and substituted or unsubstituted C1-C6 alkyl. The compound has the effect of reducing biological injury caused by ionizing radiation and also has the effects of prolonging the lifetime of radiated animals and increasing the survival rate of the radiated animals.

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