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发明授权
CN106432014B 胺基硫醇类化合物及其制备方法和其在辐射防护中的应用 有权 转让

胺基硫醇类化合物及其制备方法和其在辐射防护中的应用
摘要：
本发明公开了胺基硫醇类化合物及其制备方法和其在辐射防护中的应用，所述的化合物具有式I的结构：其中，A1选自：‑C(O)NR8‑、‑S(O)2‑NR8‑、‑S(O)NR8‑、‑R7‑NR8‑，A2选自：羰基、磺酰基、亚硫酰基、取代或未取代的C1‑6烷基，R1、R2、R5、R6可相同或不同，选自：氢、取代或未取代的C1‑C5烷基或杂烷基，n为0‑20000的整数，R3、R4独立地选自：氢、X、取代或未取代的C1‑6烷基，X选自：F、Cl、Br、I，R7选自：取代或未取代的C1‑C6烷基，R8选自：氢、取代或未取代的C1‑C6烷基。所述化合物具有降低电离辐射引起的生物损伤的作用，同时还具有延长被辐射的动物生存期和存活率的作用。
摘要（英）：

The present invention discloses an amino mercaptan compound, preparation method thereof and use thereof in radiation protection. The compound has the structure of formula I, wherein Ais selected from -C(O)NR-,-S(O)-NR-, -S(O)NRor -R-NR-; Ais selected from carbonyl, sulfonyl, sulfinyl, substituted or unsubstituted Calkyl; R, R, R, and Rmay be the same or different and are selected from: hydrogen, substituted or unsubstituted C-Calkyl or heteroalkyl; n is an integer from 0 to 20,000; Rand Rare independently selected from hydrogen, X, substituted or unsubstituted Calkyl; X is selected from F, Cl, Br or I; Ris selected from substituted or unsubstituted C-Calkyl; and Ris selected from hydrogen, substituted or unsubstituted C-Calkyl. The compound has the effects of reducing the biological damage caused by ionizing radiation, extending the survival period and survival rate of the radiated animals, and significantly alleviating the side effects of radiotherapy, and has a low toxicity. The present invention opens up a new way for protection and treatment of ionizing radiation damage.

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