The present invention relates to a N-(thiazol-2-yl)aminoamide derivative represented by a chemical structure formula I, or a salt thereof, wherein R is selected from C1-C2 alkyl, C3-C4 linear chain alkyl or C3-C4 branched chain alkyl, Y1 and Y3 are selected from hydrogen, methyl, ethyl, hydroxy, methoxy, ethoxy, fluorine, chlorine, bromine and iodine, Y2 and Y4 are selected from hydrogen, methyl, and ethyl, n is selected from 1-5, R1 and R2 are selected from hydrogen, C1-C2 alkyl, C3-C6 linear chain alkyl or C3-C6 branched chain alkyl, C3-C6 alcyl, allyl, benzyl, and hydroxyethyl, NR1R2 is selected from piperidyl, morpholinyl, piperazinyl and N-methylpiperazinyl, and the salt is selected from hydrochloride, hydrobromide, sulfate, nitrate, phosphate, methanesulfonate, benzenesulfonate, p-toluenesulfonate, malate, lactate, succinate, maleate, and fumarate. The invention further provides applications of the N-(thiazol-2-yl)aminoamide derivative or the salt thereof in preparation of anticancer drugs.