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发明授权
CN106478777B 具有免疫保护性的金黄色葡萄球菌FnBPA-A蛋白模拟表位肽、模拟表位肽组合物及其应用 有权

具有免疫保护性的金黄色葡萄球菌FnBPA-A蛋白模拟表位肽、模拟表位肽组合物及其应用
摘要：
本发明涉及具有免疫保护性的金黄色葡萄球菌FnBPA‑A蛋白的模拟表位肽、模拟表位肽组合物及其应用。本发明提供的2个免疫保护性模拟表位肽的氨基酸序列分别如SEQ ID NO:1和SEQ ID NO:2所示，而模拟表位肽组合物则由SEQ ID NO:1和SEQ ID NO:2所示的2种多肽组成，且SEQ ID NO:1所示多肽与SEQ ID NO:2所示多肽的质量配比为2:1。实验动物免疫保护性试验表明，本发明的2个模拟表位肽能够刺激机体产生高水平的特异性抗体，具有一定程度的免疫保护性，并且模拟表位肽组合物对黄色葡萄球菌感染的免疫保护效果好于FnBPA‑A全蛋白。因此，本发明的模拟表位肽及其组合物可作为有效成分，用于金黄色葡萄球菌多表位疫苗的开发，预防金黄色葡萄球菌引起的奶牛乳腺炎。
摘要（英）：

The invention relates to staphylococcus aureus FnBPA-A protein mimic epitope peptides having immunizing protection, a mimic epitope peptide composition, and applications of the mimic epitope peptides and the mimic epitope peptide composition. Two immunoprotective mimic epitope peptides provided by the invention have the amino acid sequences respectively shown in SEQ ID NO:1 and SEQ ID NO:2, the mimic epitope peptide composition consists of two polypeptides shown in SEQ ID NO:1 and SEQ ID NO:2, and the mass ratio of the polypeptide shown in SEQ ID NO:1 to the polypeptide shown in SEQ ID NO:2 is 2 to 1. Experiment animal immunoprotective tests show that the two mimic epitope peptides can stimulate a body to produce high-level specific antibodies and have a certain degree of immunizing protection; moreover, the mimic epitope peptide composition has the immunoprotective effect on staphylococcus aureus infection better than that of an FnBPA-A holoprotein. Therefore, the mimic epitope peptides and the composition thereof can be used as effective components for development of multi-epitope vaccines of staphylococcus aureus and prevention of cow mastitis caused by staphylococcus aureus.

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