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发明授权
CN106478803B 花姬蛙促胰岛素释放肽及其基因和在制药中的应用 失效 - 权利终止

花姬蛙促胰岛素释放肽及其基因和在制药中的应用
摘要：
本发明涉及花姬蛙促胰岛素释放肽及其基因和在制药中的应用，所述花姬蛙促胰岛素释放肽由33个氨基酸组成的环肽，分子量3535.14道尔顿，等电点10.3，其氨基酸序列如SEQ ID NO.1所示，上述多肽的第四位半胱氨酸和第九位半胱氨酸相成分子内二硫键。所述花姬蛙促胰岛素释放肽的基因序列由SEQ ID NO.4组成，其中编码有功能的成熟花姬蛙促胰岛素释放肽是第379‑477位核苷酸。本发明由花姬蛙促胰岛素释放肽的基因推导其成熟功能多肽氨基酸序列，合成的花姬蛙促胰岛素释放肽具有很好的促进胰岛素释放作用，同时还具有细胞毒性、无血浆凝固活性等优点，可作为制备治疗糖尿病药物的应用。
摘要（英）：

The invention relates to microhyla pulchra insulinotropic peptide and gene and pharmaceutical application thereof. The microhyla pulchra insulinotropic peptide is cyclopeptide composed of 33 amino acids, molecular weight is 3535.14 Dalton, isoelectric point is 10.3, an amino acid sequence of the peptide is shown as SEQ IN NO.1, and the fourth cysteine and the ninth cysteine of the polypeptide form an intramolecular disulfide bond. A gene sequence of the microhyla pulchra insulinotropic peptide is shown as SEQ ID NO.4, wherein mature microhyla pulchra insulinotropic peptide coded with a function is the 379th -477th nucleotides. A mature functional polypeptide amino acid sequence is deducted from the gene of the microhyla pulchra insulinotropic peptide, the synthetic microhyla pulchra insulinotropic peptide has good insulinotropic effect, has the advantages of cytotoxicity and plasma clotting inactivity and can be applied in preparing antidiabetic.

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