The invention discloses a system of generating a high dynamic range image based on heterogeneous computing. The system comprises a central processing unit which receives multiple frames of images continuously photographed at different exposures; a graphic processing unit and a memory, wherein under the control of the central processing unit, the graphic processing unit determines the weight of each pixel point in the aligned multiple frames of images, calculates the relative weight of the pixel of each frame of the aligned multiple frames of images with respect to a reference frame pixel, applies each relative weight to the weight of each pixel point in the aligned multiple frames of images to form a weight without ghosting, and synthesizes a Laplacian Pyramid of the images based on the weight without ghosting; and the central processing unit generates the high dynamic range image by utilizing the Laplacian Pyramid of the images.