The invention discloses a traditional Chinese and western medicinal composition for treating toothache and a preparation method of the traditional Chinese and western medicinal composition. The composition is prepared from western medicinal components and traditional Chines medicinal components, wherein the western medicinal components comprise erythromycin tablets, metronidazole tablets, diclofenac tablets, anluotone tablets, dexamethasone tablets, phenylbutazone tablets and anodyne tablets; the traditional Chinese medicinal components comprise herba asari, radix angelicae dahuricae, radix saposhnikoviae, pericarpium zanthoxyli, borneol, reed rhizome, herba schizonepetae, clovershrub root, cape jasmine fruit, herb of Chinese brake, fruit of pungent litse, liquorice root, paniculate swallowwort root, rhizoma cyperi and hawthorn fruit. The traditional Chinese medicinal formula disclosed by the invention replaces sodium bicarbonate tablets for conditioning intestines and stomach, so that side effects of nausea, emesis, gastrointestinal discomfort, abdominal pain, diarrhea and the like caused by the stimulation of erythromycin, metronidazole and phenylbutazone to the intestines and stomach are effectively avoided; meanwhile, an analgesic effect is improved. Medicinal accessories are mixed by using an improved mixer, so that the shaking preventing performance and the stability of a case are greatly improved, the efficiency of preparing the medicine is improved, and the production cost of the medicine is reduced.