The invention discloses a comprehensive recycling method of metal copper and zinc in lead-contained industrial waste residues. The comprehensive recycling method comprises the following steps of A, high-pressure separation of lead from copper and zinc through sulfuric acid; B, preparation of extraction liquid; C, extraction of the copper; D, extraction of the zinc. According to the method, after an impurity removal reaction and an acid leaching reaction are conducted, the lead in the lead-contained multi-metal waste residues enters a solution, and an electrolyte solution required by electro-deposition of the lead is obtained; and the copper, the zinc and other impurities are removed, so that separation of the copper and the zinc from the lead is achieved. The comprehensive recycling method is simple in process, reliable and feasible; and the valuable metal lead in the lead-contained multi-metal can be effectively recycled. By means of the method, it is beneficial to reduction of environmental pollution and recycled utilization of resources, and considerable economic benefits can also be obtained by recycling the valuable metal; lead-contained multi-metal waste in the whole smelting industry can be better recycled and utilized, the whole technique process forms a closed-circuit circulation system, and no pollution is caused to the environment; and by means of the method, effective extraction of the valuable metal copper and zinc is achieved.