The invention discloses a making method of pleurotus nebrodensis soybean milk juice, and belongs to the field of beverage processing. The making method is characterized in that pleurotus nebrodensis and soybeans are used as raw materials. A processing technology of the pleurotus nebrodensis soybean milk juice comprises three steps of: I, selecting the pleurotus nebrodensis, cleaning the selected pleurotus nebrodensis, precooking the cleaned pleurotus nebrodensis, and mashing the precooked pleurotus nebrodensis so as to obtain pleurotus nebrodensis juice; II, thoroughly cleaning soybeans, soaking the cleaned soybeans, peeling the soaked soybeans, grinding the peeled soybeans, and performing separation so as to obtain soybean milk; and III, mixing and blending the pleurotus nebrodensis juice with the soybean milk, performing homogenizing, performing deaeration, performing filling, performing sealing, performing sterilization, and performing heat preservation so as to obtain finished products. The making method disclosed by the invention has the beneficial effects that the juice of products is milky yellow, the products have specific delicious taste of the pleurotus nebrodensis and the refreshing fragrance of the soybean milk, are delicately fragrant and refreshing, fine, smooth, high in nutrient value, easy to digest, are also capable of regulating the physiologic equilibrium of human bodies, have the effect of enhancing the immune function of the human bodies, have the health-care efficacies of removing food stagnancy, relieving a cough and the like, and are simple to operate and easy to implement.