The invention discloses a compound as shown in the formula (I), (II) or (III), or salt of the compound acceptable in pharmacy, aquo-complex, a solvate, a polymorphic substance, a tautomer or a prodrug; a synthetic method of the formula (I) comprises the following steps: 5-bromo-2-aminobenzoic acid is subjected to cyclization and chlorine substituting sequentially, a product reacts with benzyl alcohol or benzyl amine, and a product is coupled with boric acid ester; a synthetic method of the formula (II) comprises the following steps: 2-aminonicotinic acid is subjected to bromine substituting, cyclization and chlorine substituting sequentially, a product reacts with benzyl alcohol or benzyl amine, and a product is coupled with boric acid ester; a synthetic method of the formula (III) comprises the following steps: 5-bromo-2-aminobenzoic acid is subjected to cyclization with dicyandiamide, deamidination is carried out, a product is condensed with benzyl alcohol or benzyl amine, and then a product is coupled with boric acid ester. A medicine composition comprises at least one of the following active components: an active compound, salt of the active compound acceptable in pharmacy, the aquo-complex, the solvate, the polymorphic substance, the tautomer or the prodrug. The invention also discloses an application of the active component in preparing a tyrosine kinase inhibitor, or an application of the active component in preparing an anti-tumor drug. Synthetic series compounds and derivatives thereof have higher tyrosine kinase inhibitory activity.