The invention discloses a manufacturing method for a large hollow grinding ball and belongs to the field of metal abrasion-resistant materials. The manufacturing method for the large hollow grinding ball comprises the following steps of 1, mold preparation and assembly, 2, coating smearing, 3, molding, 4, melting and pouring and 5, heat treatment. In the fourth step, the temperature of the cleaned cast steel hollow grinding ball is controlled to be maintained at 200 DEG C or above; in the fifth step, cast steel hollow grinding ball with the temperature being maintained at 200 DEG C or above is placed in a heating furnace with the initial temperature being 200-250 DEG C, the temperature is raised for 5 hours to 395-405 DEG C, heat preservation is conducted for 2 hours, then the temperature is raised for 7 hours to 675-685 DEG C, heat preservation is conducted for 3 hours, the temperature is raised for 2.5 hours to 845-855 DEG C, and the grinding ball is discharged out of the furnace for air cooling after heat preservation for 6 hours and subjected to tempering after being cooled to the room temperature. The manufacturing method has the remarkable control effect on the grinding ball surface defects.