The invention discloses a novel coix seed rice wine and a brewing method thereof. The novel coix seed rice wine provided by the invention comprises the following main raw materials: coix seed, tartary buckwheat, yam, poria cocos and wolfberries. The brewing method comprises the following steps: baking the coix seed; compounding and steaming the raw materials; saccharifying with Xiaoqu, fermenting with Muqu and performing proteolysis through rice wine distiller grains; blending the bulk wine with the hydrolysate, thereby obtaining a health-care coix seed rice wine rich in nutritional ingredients and special in coix seed flavor. The coix seed rice wine provided by the invention is rich in various function ingredients, such as, polysaccharide, polypeptide, flavones and coix seed grease, is high in nutritive value, is low in alcohol content, is unique in flavor and has the healthcare effects of adjusting immunity, relieving fatigue, and the like.