The invention provides paste with anti-parasitic medicines such as ivermectin for animals. The paste has the advantages that the paste is prepared by the aid of self-emulsification technologies and emulsification technologies, in other words, selected specific surfactants and selected oil media are combined with one another, and accordingly the paste with excellent effects of 'isolating' oxygen, hydrogen ions and hydroxide ions can be prepared; the prepared paste is good in stability and water solubility, and excellent acid-tolerant or alkali-tolerant catalytic degradation effects and antioxidant effects can be realized by the paste; the paste can bring convenience for medicine administration and is particularly convenient as compared with tablets when the paste is used for preventing and treating parasitic diseases for horses, cattle, sheep, pet cats and dogs; the tablets need to be delivered into the oral cavities when about to be fed to animals or even need to be delivered to the pharynxes by the aid of medicine feeders, but the medicines in the paste can be smeared on the lips of the animals and positions near the lips, and the animals can lick the medicines into the mouths by the aid of licking behavior of the animals (for example, the pet cats have strong habit of licking a plurality of positions of the bodies, and the cattle, the sheep and the dogs have such habit of licking the lips.).