The invention relates to a method for reducing cold rolling inclusion defect through optimization of IF (Interstitial-Free) steel smelting parameters and belongs to the field of iron and steel metallurgy smelting production. The technical scheme of the method includes the steps of collecting production data from a converter to cold rolling, and associating the collected data so that inclusion defect situations recorded in cold rolling and hot rolling production processes correspond to charge data in a smelting process; obtaining the influences of key parameters in smelting on the inclusion defects of rolled metals and the mutual relation of smelting parameters, and finding out a key factor which exerts a great influence on the inclusion defects of the rolled metals; and proposing an improvement of technological parameters according to the key factor and thus effectively reducing a ratio of the inclusion defect in the rolled metal. The method has the beneficial effects that the improvement of the technological parameters is proposed according to the key factor, thus the ratio of the inclusion defect in the rolled metal is effectively reduced, and the method provides a basis for iron and steel enterprises to diagnose the smelting technology and reduce the cold rolling inclusion defect.