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发明公开
CN106866792A 一类环十肽分子及其应用 有权

一类环十肽分子及其应用
摘要：
本发明公开了一类环十肽分子及其应用。该环十肽分子通式为Cyclo(X‑dY‑Z‑W‑Arg‑Leu‑dY'‑Z'‑W'‑Arg)，其中X为Leu，Ala或Val中的一种；dY与dY’为dPhe，dAla或dVal中的一种；Z与Z’为Pro或Ala其中的一种；W与W’为Ala,Thr或Val其中的一种；且当X为Leu且dY与dY’同为dPhe，Z与Z’同为Pro时，W与W’不同时为Val。所述环十肽分子可以通过防止Ab毒性寡聚体的形成，以及清除模式动物脑内的Ab斑块，从而有效地降低由Ab引起的神经细胞损害，对与Aβ相关的疾病，包括青光眼，老年性眼底黄斑变性以及阿尔兹海默症中具有良好的治疗效果。
摘要（英）：

The invention discloses a cyclic decapeptide molecule and application thereof. The general formula of the cyclic decapeptide molecule is Cyclo(X-dY-Z-W-Arg-Leu-dY'-Z'-W'-Arg), wherein X represents one of Leu, Ala or Val; dY and dY' represent one of dPhe, dAla or dVal; Z and Z' represent one of Pro or Ala; W and W' represent one of Ala, Thr or Val; and when X represents Leu and dY, dY' simultaneously represent dPhe and Z and Z' simultaneously represent Pro, W and W' do not simultaneously represent Val. According to the cyclic decapeptide molecule, by preventing formation of Ab toxic oligomers and eliminating Ab plaques in brains of model animals, nerve cell injury caused by Ab is effectively reduced; and the cyclic decapeptide molecule has good treatment effects to Abeta relevant diseases such as glaucoma, Age-related macular degeneration and Alzheimer's disease.

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