The invention provides drilling cleaning circulation equipment, and relates to the technical field of underground excavation construction of subway tunnels. The equipment comprises a drilling machine, a mud separation device, a mud tank and pipelines. The pipelines comprise the first pipeline and the second pipeline, and the drilling machine is connected with a gravel pump; drilling slag, generated in drilling of the drilling machine, in a hole is pumped out through the gravel pump and then discharged to the mud separation device through the first pipeline, the mud separation device separates the drilling slag from mud, and the separated mud flows back into the mud tank; a variable-frequency mud return pump is arranged in the mud tank and used for conveying the mud in the mud tank back into the hole through the second pipeline. The drilling cleaning circulation equipment is used for pumping drilling slag and mud in a drilled hole out of the pile hole and then separating the drilling slag from the mud and can convey the separated mud back into the pile hole, and thus a mud and drilling slag mixture in the pile hole can be discharged in time to accelerate drilling of a drill.