The invention discloses a self-lubricating heterogeneous material die for hot stamping of a high-strength steel plate. The self-lubricating heterogeneous material die comprises a base body, a supporting layer, an intensified thermal insulating layer and a self-lubricating layer which are arranged in sequence, wherein the base body is made of hot work die steel; the supporting layer is made of austenitic heat-resistance steel or stainless steel electrodes; the supporting plate is arranged on the base body in a surfacing mode; the intensified thermal insulating layer is made of a metal-based ceramic material prepared by mixing tungsten carbide or chromium carbide powder and self-melting alloy powder; the intensified thermal insulating layer is arranged on the supporting layer through the powder plasma spray-welding technology in a surfacing mode; the self-lubricating layer is made of a mixture of lubricating phases, bonding phases and hard phases; and the self-lubricating layer forms a coating on the intensified thermal insulating layer through a powder metallurgy sintering method. The self-lubricating heterogeneous material die for hot stamping of the high-strength steel plate, provided by the invention, meets the performance requirements for the hot stamping die in the hot stamping process of the high-strength steel plate.