The invention discloses acid-resistant and etching-resistant UV-curing printing ink. The printing ink is prepared from components in percentage by mass as follows: 10%-15% of a monomer, 50%-60% of photosensitive resin, 3%-8% of a photoinitiator and 15%-30% of powder; the monomer is a mixture of trimethylopropane trimethacrylate and isocyanurate, and the photosensitive resin is a mixture of polyether type aromatic polyurethane acrylate and phenolic epoxy acrylate. The new ratio of printing ink components and new materials are applied, so that the printing ink has excellent corrosion resistance to hydrochloric acid and other strong acids during production of high-precision etched patterns of metal base materials such as copper, aluminum, iron, stainless steel and the like, can effectively protect the gloss and basic performance of substrates and conforms to market demands and industry development. Meanwhile, the invention further discloses a preparation method of the acid-resistant and etching-resistant UV-curing printing ink.