An extravehicular maintenance ground total-factor simulation system for a manned space vehicle comprises a servo mechanism, a console, a vacuum tank, an observation window, spacesuit gloves, support guide rails, a vacuum cold-dark environment simulation subsystem, a thermal simulation subsystem, an equipment state simulation subsystem and an illumination simulation subsystem. The servo mechanism can achieve horizontal movement, vertical movement and rotation of a maintenance equipment simulation part installed on the servo mechanism, the vacuum cold-dark environment simulation subsystem can simulate the extravehicular vacuum cold-dark environment, the thermal simulation subsystem can simulate the extravehicular temperature environment, the equipment state simulation subsystem can simulate the working state of the maintenance equipment simulation part, and the illumination simulation subsystem can simulate the extravehicular illumination environment. When simulating the on-orbit extravehicular vacuum cold-dark environment, thermal, illumination and equipment working state, the extravehicular maintenance ground total-factor simulation system for the manned space vehicle simulates the pressure difference between the inside and the outside of the spacesuit gloves and the relative position between test personnel and the maintenance equipment simulation part, and thus on-orbit extravehicular maintenance ground total-factor simulation for the manned space vehicle is achieved.