The invention discloses a cross-network state reliable switching method of a 1553B bus network and a serial bus network. The method specifically comprises the following steps: (1), Smaster in the 1553B bus network sends a state switching command message to Sslave; (2) the Sslave resolves the state switching command message to obtain all stations needing to perform the state switching; (3) the Sslave forwards a switching command message to a station Ui needing to perform the state switching in the serial bus network except the Sslave, and queries a reply message with switched state; (4) the Sslave forms a cross-network state switching reply message to send to the Smaster according to each station switching state and the self state switched message; and (5) the Smaster judges whether the states of all stations needing to switch are corresponding to the sent state switching command according to the cross-network state switching reply message, thereby judging whether each station required to switch has finished the state switching. By using the method disclosed by the invention, the state control function on other station in a hybrid network by any station in the 1553B is realized.