The invention provides an application of an AZA resveratrol-chalcone derivative in preparing a drug for treating diabetic complications. The compound can achieve the effect of treating the diabetic complications in the manner of reducing the chronic inflammations and boosting the oxidation resisting action mechanism by restraining NF-kB transfer activity and activating Nrf2 signal path. The compound is optimally taken as an oral medicine (used for preparing powder, tablet, pill, oral liquid and capsule). The compound can effectively relieve the happening and development of diabetic cardiomyopathy and can become a main component in the drug for treating the diabetic complications.