The invention specifically relates to a method for large-scale production of a high-purity porcine circovirus ORF2 protein, belonging to the technical field of vaccine preparation. The method comprises the following steps: weighing a porcine circovirus ORF2 protein culture solution, adding a small amount of chitosan and carrying out natural settling after shaking up; sucking up a supernatant and subjecting the supernatant to clarification and filtering with a hollow fiber column; then carrying out ion exchanging with an ion exchange column; and subjecting an eluate to desalination with a G25 chromatographic column, degerming and filtering successively so as to obtain high-purity porcine circovirus ORF2 protein liquid. According to the invention, large-scale (500 to 1000 L) high-efficiency production of the high-purity porcine circovirus ORF2 protein is realized through processes like settlement with chemical reagents, clarification and filtering, ion exchanging, and desalination with the G25 chromatographic column; the recovery rate of the high-purity porcine circovirus ORF2 protein can reach 99.46%; the removal rate of other proteins is as high as 98.04%; and the content of effective antigens is as high as 93.2%.