The invention discloses a fluorine-containing coumarin thiazole compound and synthetic method thereof. The synthetic method includes the steps: (1) dissolving a trifluoroacetyl coumarin compound, a thiosemicarbazide compound and an acid catalyst in absolute ethyl alcohol to obtain non-substituted thiosemicarbazone solution after reaction; (2) adding 2-bromoacetophenone into the non-substituted thiosemicarbazone solution in the step (1), taking the absolute ethyl alcohol as solvents, and drying mixture at the indoor temperature to obtain the fluorine-containing coumarin thiazole compound. The synthesized coumarin thiosemicarbazide thiazole compound is a star compound and has active unit structures such as coumarin, trifluoromethyl, Schiff base and thiazole, and the compound has a large pi-pi conjugated system and is expected to become a bioactive substance with high activity or an optical active substance with high fluorescence performance.