The invention discloses a rolling method for large-wall-thickness pipeline steel. The rolling method comprises the following process steps of: (1) heating, wherein a continuously cast billet is heated by a step beam type heating furnace, heating speed is 4-5 min/cm from the room temperature, and the temperature is controlled to 800-900 DEG C at a preheating stage, heating speed is controlled to 6-8min/cm and the temperature is controlled to 1160-1180 DEG C at a heating stage, and the temperature is controlled to 1160 +/-20 DEG C and heat-preserving time is 120-160 minutes at a soaking section; and (2) rolling, wherein during rough rolling, a final rolling temperature is greater than or equal to 980 DEG C, thickness of intermediate billet ranges from 80 mm to 90 mm, a high reduction system is adopted, and a reduction rate of continuously two passes is greater than or equal to 25% after widening; during finish rolling, a rolling starting temperature is 830 DEG C, a final rolling temperature is 720-740 DEG C, and rolling is performed by two passes; during cooling, a cooling starting temperature is 690-710 DEG C, cooling speed is 15-18 DEG C/S and a final cooling temperature is 380-420 DEG C. Cast billet with section dimension of 260 mm*2280mm is utilized to produce pipeline steel which is excellent in anti-crack property and is provided with large wall thickness of 30.8 mm, pipe diameter of 1422 mm and steel grade of X80. Compared with a TMCP+OLT process, the rolling method reduces manufacturing cost, i.e., saves online tempering cost.