The invention discloses a fish bone powder and protein peptide mixture chewable tablet including, by weight, 30-50 parts of fermented fish bone powder, 16-27 parts of protein peptide powder, 0.03-0.09 parts of magnesium stearate, and 0.5-1.6 parts of SiO2. The chewable tablet has the following advantages: the proteins from marine animals are quite different from the proteins from terrestrial animals in not only constitution but also sequences of amino acids, so that by enzymolyzing marine products with marine protease, various different active peptide fragments are released; the chewable tablet is high in content of free calcium, vitamin and small molecular proteins and contains required elements such as P, Mg, Fe, Zn and the like; the chewable tablet has good calcium absorption effect to human body, and has a tendency of significant increase on calcium apparent absorption rate, calcium retention rate, bone density, bone mineral salt content, bone cortex area, femur energy absorption and the like after long time use.