The invention belongs to the field of medicinal chemistry and particularly relates to an application of asymmetric curcumine compounds to preparation of anti-gastric-cancer drugs. The compounds can effectively inhibit growth of gastric cancer cells BGC-823, SGC-7901 and MFC, inhibit formation of gastric cancer cell colonies, inhibit NF-kappaB signaling pathways in the gastric cancer cells, down-regulate expression of anti-apoptotic protein Bcl-2, up-regulate expression of apoptin Bax and induce gastric cancer cell apoptosis, wherein the active compound S06 can effectively enhance anti-gastric-cancer activity of irinotecan and can serve as a potential anti-gastric-cancer drug.