The invention relates to a high-lift and high-specific-speed mixed flow pump. The mixed flow pump comprises an elbow-shaped water inlet flow channel, an impeller, guiding blades, a water outlet bent pipe and a water outlet flow channel, and is characterized in that the impeller comprises blades, a hub and a water guiding cone, the asymmetric wing-shaped blades are uniformly arranged on the hub in a circumferential direction, and the water guiding cone is arranged at the front end of the hub; and the blades are in shapes being thick in the middle and thin on the two sides, and are provided with three-dimensional twisted curved surfaces. According to the mixed flow pump, the operation efficiency of the mixed flow pump can be effectively improved, and the mixed flow pump is suitable for a high-lift pump station.