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发明公开
CN107522773A 一种五肽改性罗丹明B化合物及其制备方法和应用 失效 - 权利终止

一种五肽改性罗丹明B化合物及其制备方法和应用
摘要：
本发明涉及一种五肽改性罗丹明B化合物及其制备方法和用途，所述五肽改性罗丹明B化合物具有式Ⅰ的化学结构式。本发明提供的五肽改性罗丹明B化合物具有肿瘤靶向性或选择性，作为荧光成像的示踪剂可实现肿瘤靶向成像，提高成像对比度和清晰度，另外，本发明提供的五肽改性罗丹明B化合物使用剂量比罗丹明B可以减少一半，而且水溶性好，便于配成溶液进行灌注或注射使用。式Ⅰ：
摘要（英）：

The invention relates to a pentapeptide modified rhodamine B compound as well as a preparation method and application thereof. The pentapeptide modified rhodamine B compound is of a chemical structural formula of formula I as shown in the specification. The pentapeptide modified rhodamine B compound provided by the invention has tumor targeting or selectivity and is capable of achieving tumor targeting imaging when being used as a fluorescence imaging tracer agent and improving the imaging comparison and clarity. In addition, the use dosage of the pentapeptide modified rhodamine B compound provided by the invention is reduced by half when being compared with that of rhodamine B, and the compound is good in water solubility and convenient to prepare into solutions for perfusion or injection.

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