The invention relates to a comprehensive treatment method for lead-containing dedusting ash. The method comprises the following steps: introducing lead-containing dedusting ash into an air classification-air and magnetic sorting system, separating large-grain dedusting ash out through air classification so as to obtain an air-sorted iron ore concentrate, and separating magnetic materials in fine-grain dedusting ash out through air and magnetic sorting so as to obtain a magnetically-sorted iron concentrate; returning the air-sorted iron ore concentrate and the magnetically-sorted iron concentrate to sintering and smelting procedures; subjecting dry tail ash captured by a bag-type dust collector to lead removal and lead extraction; and mixing the dry tail ash with a ground carbon-containingreducing agent, a binder and water to prepare agglomerate and roasting the agglomerate to obtain metalized agglomerate which is applied to blast furnaces and converters; and wherein dedusting ash in aflue gas recovery system is lead-rich ore powder and can be used a raw material for lead refining and lead extraction. The comprehensive treatment method provided by the invention avoids the problemsof wasting of resources and energy, low cost performance of treatment and the like caused by great fluctuation of lead content in lead-containing dedusting ash and unreasonable process design of conventional treatment processes; and the comprehensive treatment method reduces the harm of heavy metal lead to a smelting system and turns the waste lead-containing dedusting ash into the valuable.