The invention provides an opening and closing device for a vehicle door and a manufacturing method thereof. The device has an open cable having one end connected with an internal door handle of the vehicle door, and having a cable end arranged at the other end of the open cable and having a larger radial size than the open cable; and a movable element connected to the open cable and the latch unitof the vehicle door, the open cable is rotated in a first direction when the open cable is pulled towards the internal door handle in the door opening operation of the internal door handle, and the operation of the external door handle of the vehicle door is also rotated in the first direction, the latch unit is started by the rotation of the movable element in the first direction, so that the firing pin of the vehicle is disengaged, and the movable element is provided with a guide retainer, the retainer is used for keeping the cable end, and the cable end is prevented from moving towards theinternal door handle when the internal door handle is operated in the door opening direction, when the internal door handle is operated in the door closing direction, the cable end is allowed to movein the direction away from the internal door handle.