The invention discloses a control device for eliminating microorganisms in a human body during a manned spacecraft AIT period. The device comprises a structure subsystem, a lighting ventilating subsystem and a controlling and sterilizing subsystem, wherein a 20-inch container is reconstructed into a male dressing room, a female dressing room and an intermediate aisle; the male dressing room and the female dressing room are symmetric to each other; an air showering buffering area is arranged in the aisle; dressing devices and sterilizing and disinfecting devices are arranged in the male dressing room and the female dressing room; the air quality and the environment quality in the dressing rooms are ensured through various detecting devices. According to the device, a multi-level secondary clean people dressing environment is provided; the clothing use time is automatically monitored; the dressing environment is automatically disinfected; people can disinfect the hands; the microorganismcontrol effect is pre-warned and quantitatively recorded; and meanwhile, the demand that the dressing rooms quickly run as the spacecraft transports is met; and the pollution of the microorganisms inpeople at the manned spacecraft AIT period to the spacecraft can be avoided.