The invention discloses a multi-joint anti-resistance exercise device and relates to the technical fields of aerospace medicine and exercise rehabilitation. The multi-joint anti-resistance exercise device comprises a waist support, a thigh connecting plate, a shank connecting plate and a foot supporting plate; the side wall of the waist support is connected with a hip joint damper, and the bottomof the hip joint damper is connected with the top of the thigh connecting plate; the bottom of the thigh connecting plate is connected with the top of the shank connecting plate by virtue of a knee joint damper, and the bottom of the shank connecting plate is connected with the foot supporting plate. The multi-joint anti-resistance exercise device disclosed by the invention has the advantages thata low-damping load can be applied to each joint of lower limbs for a long time, and damping provided by the device is overcome without limiting a human body activity range by virtue of active movement of a human body or some special exercise activities, so that the aims of exercising muscles and reducing muscle atrophy of the human body and bone loss are achieved; meanwhile, resistance received by each joint can be controlled, different exercise intensity demands of the human body are met, and exercise damage is avoided.