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发明公开
CN107814708A 一种拆分剂奎宁的回收套用方法 无效 - 撤回

一种拆分剂奎宁的回收套用方法
摘要：
本发明涉及一种制备盐酸帕洛诺司琼关键中间体(S)-1,2,3,4-四氢-1-萘甲酸所用拆分剂奎宁的回收套用方法，它是以消旋的1,2,3,4-四氢萘甲酸的拆分结晶母液为原料，经酸化后，萃取分离，然后再碱化，分离出有机相，最后浓缩重结晶得到旋光度合格的奎宁，可以再次用于对1,2,3,4-四氢萘甲酸进行拆分。本发明通过对制备(S)-1,2,3,4-四氢-1-萘甲酸反应废液中的拆分剂奎宁的回收套用，大大降低了生产成本，减少了含氮废液的排放，有利于环境保护，且工业操作简单，易于实现工业化。
摘要（英）：

The invention relates to a recovering and reusing method of a resolving agent quinine for preparing a key intermediate S-1,2,3,4-tetrahydro-1-naphthoic acid of palonosetron hydrochloride. The recovering and reusing method comprises the following steps: taking a resolving and crystallizing mother solution of racemic 1,2,3,4-tetrahydronaphthoic acid as a raw material; acidifying and carrying out extracting separation; then alkalinizing and separating out an organic phase; finally, concentrating and recrystallizing to obtain quinine with qualified optical rotation, wherein the quinine can be usedfor resolving the 1,2,3,4-tetrahydronaphthoic acid again. According to the recovering and reusing method disclosed by the invention, by recovering and reusing the resolving agent quinine in reactingwaste solution generated by preparing an S-1,2,3,4-tetrahydro-1-naphthoic acid, the production cost is greatly reduced, discharge of a nitrogen-containing waste solution is reduced and environmental protection is benefited; in addition, the recovering and reusing method is simple in industrial operation and easy for industrialization realization.

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