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发明授权
CN107827916B 一种(R)-(1-氨基-3-甲基)丁基-1-硼酸蒎烷二醇酯的合成方法 有权 转让

一种(R)-(1-氨基-3-甲基)丁基-1-硼酸蒎烷二醇酯的合成方法
摘要：
本发明公开了一种(R)‑1‑氨基‑3‑甲基丁基‑1‑硼酸蒎烷二醇酯(式I)的合成方法，该合成方法以(R)‑1‑氨基‑3‑甲基丁烷‑1‑硼酸频那醇酯盐酸盐为原料，经氨基保护、硼酯交换及脱保护得到目标产物。本发明的方法具有反应步骤少、反应条件温和、所用试剂价格低廉、产品纯度高等优点，利于工业化生产。
摘要（英）：

The invention discloses a synthetic method of (R)-(1-amino-3-methyl) butyl-1-pinane borate terephthalate (The formula I). The synthetic method is characterized in that (R)-1-amino-3-methyl butane-1-boronic acid pinacol ester hydrochloride is taken as a raw material, and a target product is obtained by amino protection, boron ester exchange and deprotection. The method disclosed by the invention has the advantages of fewer reaction steps, mild reaction conditions, low price of used reagents, high purity of products and the like; in addition, the industrial production is facilitated.

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