The invention provides a novel high-penetration prodrug composition and a medicinal composition for treating lung diseases. A high-penetration composition (HPC)/a high-penetration prodrug (HPP) can betransformed into a parent active medicine (parent medicine) or a metabolin thereof after penetrating through a biological barrier, so the HPC/HPP can treat diseases which can be treated by the parentmedicine or the metabolin thereof. In addition, the HPP can arrive at the target position where the parent medicine cannot enter or cannot achieve the effective concentration, so new treatment is provided. The HPC/HPP can be applied to a living body through various administration routes, for example, the HPC/HPP can obtain high concentration through local administration at the generation positionof the disease and can enter the whole circulation system at high speed when being applied to the living body system.