The present invention provides a power distribution network comprehensive evaluation method based on a grey target model of positive and negative target centers, and belongs to the power distributionnetwork comprehensive evaluation field. The power distribution network comprehensive evaluation method comprises the steps of selecting the power distribution network evaluation indexes from a power distribution network supply side; selecting a theoretical optimal value, an actual value, a qualified upper limit value, a qualified lower value, a theoretical worst value and an actual worst value from the evaluation indexes, and calculating an optimal value vector, a worst value vector and a qualified value vector; for the optimal value vector, the worst value vector and the qualified value vector, utilizing the range transformation principle of an interval grey number to eliminate the dimension influence to calculate a positive target center, a qualified target center and a negative target center. The method of the present invention solves the problem that the conventional grey target model is not suitable for evaluating the power distribution network in a single region, improves the grey target model of the positive and negative target centers, avoids the situation that when the weights are calculated via a link-relative method, the importance between the indexes is fuzzy, can evaluate the power distribution network in the single region and in the multiple regions, and has the advantages of being scientific and reasonable, being strong in applicability and good in effect, etc.