The invention discloses a preparation method for two-color oil-proof antibacterial food packaging paper. Components of a slurry are optimized, a filler is pretreated and modified, a multilayer headboxis adopted to adjust and control the components and ratio of the slurry in each layer, and therefore the two-color oil-proof antibacterial food packaging paper is prepared. The food packaging paper provided by the invention is beautiful, can play a dual antibacterial effect, does not fall hairs or powder, and has the characteristics of health and environmental protection.