The invention discloses an omnidirectional intelligent mobile equipment positioning and navigation method based on laser ranging, which comprises the following steps: installing a sensor on an AGV, and measuring the distance from the center of the sensor to the center of the AGV; installing a laser reflector in the AGV operating site; setting the initial origin and zero angle of the sensor, usinga navigation controller to collect the real-time pose information of the sensor and filter it to obtain the current pose information of the sensor; obtaining the current pose information of the body center of the AGV through a conversion formula; and when the AGV performs patrol running, timely solving the deviation of the current pose information of the body center of the AGV from the target path, and timely adjusting the angular velocity and the yaw angle of the AGV according to the deviation to complete the navigation. The method arranges the sensor and the laser reflector, solves the deviation of the AGV pose and the target path in real time, and adjusts the AGV according to the deviation in real time, thereby realizing the flexible setting of the AGV running route and accurate navigation, and making up defects of the traditional laser navigation AGV positioning method that the path is single and the reliability is poor.