A method of compensating for integral nonlinear interpolation (INL) distortion in a clock synthesizer driven by a system clock running at a frequency fsys, involves introducing a selected nominal analog delay I*dt with an actual delay of I*dt+δ at the output of the a first path with a digital controlled oscillator (DCO) and a digital-to-time converter (DTC) and a nominal digital delay I*D with an actual delay of I*D+Δ at the input of a second path with a DCO and a DTC that offsets the actual analog delay in the first path, adjusting the contents x(k) of a compensation module in the second path to align the output pulses of the first and second paths for different values of k, where k represents an interpolation point, iteratively repeating the two preceding steps for all N values of I, and averaging the contents x(k) of the compensation module to derive the compensation values to be applied to a one of the DTCs to correct for INL distortion.