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发明公开
CN108348612A 包含氨基硫羟酸酯化合物或其药学上可接受的盐、与能够增加受试者的癌细胞中H2O2水平的化合物的组合 审中-实审

包含氨基硫羟酸酯化合物或其药学上可接受的盐、与能够增加受试者的癌细胞中H2O2水平的化合物的组合
摘要：
用作药物的包含氨基硫羟酸酯化合物或其药学上可接受的盐与能够增加受试者的癌细胞中H2O2水平的化合物的组合。本发明涉及包含氨基硫羟酸酯化合物或其药学上可接受的盐、特别是S-甲基4-(二甲氨基)-4-甲基戊-2-炔硫代酸酯或其药学上可接受的盐、且更具体地为4-(二甲氨基)-4-甲基-2-戊炔硫代酸S-甲基酯富马酸盐、与能够增加受试者的癌细胞中H2O2水平的化合物的组合，该组合特别的用于治疗受试者的癌症，其中所述受试者的癌细胞与对照值相比不过度产生H2O2、并且对于25000个细胞具有低于5nmol的GSH水平。
摘要（英）：

Combination comprising an aminothiolester compound or a pharmaceutically acceptable salt thereof and a compound able to increase the H 2 0 2 level in cancer cells of a subject, for use as a medicament The present invention relates to a combination comprising an aminothiolester compound or a pharmaceutically acceptable salt thereof, in particular the S-methyl 4-(dimethylamino)-4-methylpent-2-ynethioate or a pharmaceutically acceptable salt thereof, and more particularly the 4-(Dimethylamino)-4-methyl-2-pentynethioic acid S-methyl ester fumarate, and a compound able to increase H 2 0 2 level in cancer cells of a subject, in particular for use for the treatment of cancer in a subject, wherein cancer cells of said subject do not overproduce H 2 0 2 in comparison to a control value and have a level of GSH below 5 nmol for 25000 cells.

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