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发明授权
CN108383761B 2-芳基砜基-2，2-二氟重氮乙烷化合物及其制备方法与应用 失效 - 权利终止

2-芳基砜基-2，2-二氟重氮乙烷化合物及其制备方法与应用
摘要：
本发明涉及2‑芳基砜基‑2，2‑二氟重氮乙烷化合物及其制备方法与应用。本发明的2‑芳基砜基‑2，2‑二氟重氮乙烷化合物的制备方法：将2，2‑二氟‑2‑芳基砜基乙胺盐酸盐溶解于有机溶剂和水的混合溶剂中，加入亚硝酸盐，室温搅拌完全反应后，经洗涤、萃取、分离，柱色谱纯化得黄色液体2‑芳基砜基‑2，2‑二氟重氮乙烷。所得目标化合物是含有砜基二氟甲基的重氮类化合物，可与炔烃进行【3+2】环加成反应，用于合成含有二氟甲基的吡唑类化合物。本发明的二氟重氮乙烷化合物制备方便，使用简单，反应条件温和，为含有二氟甲基化合物的合成提供了一条有效的方法。
摘要（英）：

The invention relates to a 2-arylsulfonyl-2, 2-difluorodiazoethane compound, a preparation method and application thereof. The preparation method of the 2-arylsulfonyl-2, 2-difluorodiazoethane compound includes: dissolving 2, 2-difluoro-2-aryl sulfonyl ethylamine hydrochloride in a mixed solvent of an organic solvent and water, adding nitrite, carrying out stirring at room temperature for completereaction, and then conducting washing, extraction, separation and column chromatography purification to obtain the yellow liquid 2-arylsulfonyl-2, 2-difluorodiazoethane. The obtained target compoundis a diazo compound containing sulfonyl difluoromethyl, can be subjected to [3+2] cycloaddition reaction with alkyne so as to synthesize a pyrazole compound containing difluoromethyl. The difluorodiazoethane compound provided by the invention has the characteristics of convenient preparation, simple use and mild reaction conditions, and the invention provides an effective method for synthesis of compounds containing difluoromethyl.

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