The invention relates to a spacecraft pipeline error compensation method. The method comprises the following steps that (A), a pipeline structure for a spacecraft is designed according to the structure and the function of the spacecraft; (B), for equipment in the spacecraft pipeline, (1), the equipment is subjected to positioning and installing by adopting adjustable positioning, (2), the equipment is fixedly supported and positioned through the pipeline, and (3), so that the equipment can be movably supported at least in one degree of freedom; (C), aiming at the fixation of the pipeline, thefixed pipeline can be movably fixed at least in one degree of freedom, so that the fixed pipeline can be adjusted during the fixing process; and (D), aiming at the pipeline, (1), a rigid tube is replaced with a flexible tube in the pipeline, so as to absorb the error in the pipeline, and (2), the distance between the pipeline and the equipment is increased so as to avoid mutual interference.